Economic Analysis of Patented Drugs vs. Generic Drugs Research Paper

Economic Analysis of Patented Drugs vs. Generic Drugs - Research Paper Example As for example, phenytoin which is the common name and Dilantin is the business name for a single drug. When one drug is in rights security, the company sells it with its business name. When a drug is out of the patent protection (no longer protected by patent), the company may sell the products under whichever name they want common name or business name. Other companies which file for authorization to sell that off-patent drug have to use the similar common name but have the freedom to use their own trade name. This results in drugs to be sold in the same generic name but multiple trade names. (Aronsson et al. 2001) General drugs are remedies that are known by the chemical formulae instead of their brand, or business name. Most of the people, as for example, know the brand title Valium, however the common name of the anxiety defiant drug is diazepam. (Mehta & Mehta, 1997) In the most cases, most drugs are likewise as efficient as brand-name remedies. They too are typically lesser ex pensive than the brand names, frequently as a great deal as 50 % or more. What is the reason behind this? (Mehta & Mehta, 1997; Aronsson et al. Pharmaceutical industries spend a lot of time (usually a decade or more) and cash—generally more money than $300 million—to research, develop, produce, and marketing a brand new drug. Which results in, if the efforts become positive, the brand-name drug which is patented plus sold solely under a particular business name for seventeen years, which permits the industry get back more money than it invested. As a patent runs out, or there is not any patent at all, other industries can produce and market that drug with the drug’s common name or with other brand names. ... As a patent runs out, or there is not any patent at all, other industries can produce and market that drug with the drug’s common name or with other brand names. Other industries don’t need to invest the time and wealth to get the actual drug to the market. Therefore, they can sell the drug at a lower cost. (Mehta & Mehta, 1997; Aronsson et al., 2001) Economic analysis of patent protection versus generic drugs: The limit of the patent security in helping the mechanisms for making novel remedies not supposed to be minimized. To get a fresh prescription remedy in the market, industries of pharmaceutics must beat several obstacles including large investments for researching and development (R&D), authoritarian scrutiny very importantly scientific trustworthiness corresponding the protection and effectiveness of that fresh drug. To attain this, companies continuously search for fresh compounds having medicinal power. When a brand new, hopeful substance is found, the industr y files a request for patent security while it goes through different levels of Research and Development. Current estimations of the expense of developing a fresh drug is ranged between $230 million and $500 million prior to the remedy can be marketed. (Mehta & Mehta, 1997) Getting patent security for a particular remedy, the industry has the power to set the price as per wish; without contest, no descending pressure is there upon the price from different probable drug providers. The monopoly supremacy gained from that patent protection gives inducement for drug industries to put in a big capital needed for Research and Development by permitting them in earning much more than the possible result in more contesting market. With no

Laser Eye Surgery Essay Example for Free

Laser Eye Surgery Essay Laser eye surgery has enabled millions of people to throw away their eyeglasses. Now several medical technology companies are hoping that lasers aimed at the feet will allow millions to take their socks off, even in public. The target is toenail fungus — an infection in an estimated 10 percent of American adults, or 23 million people — that causes toenails to become thick, yellow and fetid. If these lasers, which recently completed small clinical trials, work, they will represent a new way to treat nail infection by selectively irradiating fungi while leaving the nail and surrounding tissue intact. Right now, there is no sure cure. The fungi are so hardy that popular antifungal pills, which carry a small risk of liver damage, are completely successful less than half of the time. And a prescription lacquer, painted on the toenails daily for 48 weeks, has a complete cure rate of less than 10 percent. Pharmaceutical giants like Schering-Plough and Novartis are developing new lacquers, pills and ointments to battle the fungi. But some podiatrists and patients are pinning their hopes on the experimental laser treatments. Nomir Medical Technologies in Waltham, Mass., is developing a laser called Noveon for diseases like antibiotic-resistant staph infections as well as nail afflictions. Noveon is a type of laser already commonly used by doctors for treatments like cataract surgery, dental work and even hair removal. Noveon beams two different wavelengths of near-infrared light at toenails to selectively take aim at and kill fungi. After four treatments with Noveon, about half of the 39 toenails tested no longer had active nail infections, according to the results of a clinical trial that the company presented this month at a national dermatology  meeting. Six months after the initial treatment, about 76 percent of the volunteers had clear nail growth, the study reported. â€Å"We will be able to reach people who have heretofore stayed away from treatment because of the toxicity or the costs or other reasons,† said Richard F. Burtt, Nomir’s chief executive. Mr. Burtt said the company was preparing to submit the data to the Food and Drug Administration, hoping to receive clearance to market Noveon by this fall. The agency has already cleared Noveon for use on the skin and in nasal passages. But the company is not taking orders for or distributing the laser for nails until it receives specific permission to do so, Mr. Burtt said. Another company developing a laser, PathoLase, is so eager to get a piece of the billion-dollar-plus market for antifungal nail treatments that it has not waited for federal permission to begin marketing its device, the PinPointe Footlaser, for use on toenail fungus. Nearly 70 podiatrists in 21 states already offer PinPointe, according to PathoLase. The treatment, which is not covered by health insurance, costs $1,000 or more. The F.D.A. requires manufacturers to wait for federal clearance before marketing a medical device for specific uses. But PathoLase appears to have jumped the gun in the war on spores. Last week, a news broadcast by a Fox affiliate in Manhattan featured PinPointe as the latest thing for nail disorders. Dr. Stuart J. Mogul, a podiatrist in Manhattan who demonstrated the laser during the broadcast, said he had recently treated four patients with PinPointe at a cost of $1,200 each. He said it was too soon to tell whether the treatment had worked. â€Å"I explain to patients that the only risk is financial,† Dr. Mogul said in an interview last week. He added that representatives of PathoLase had told him that the F.D.A. had  approved the laser as being safe. Up until Tuesday, PinPointe’s Web site promoted the toenail laser as â€Å"F.D.A. cleared† and included an endorsement from a podiatrist in California saying he had used the device for six months on 225 patients. Because the F.D.A. cleared the device in 2001 for use in dentistry, doctors are free to use it for other purposes, John Strisower, the chief executive of PathoLase, said in an interview on Monday. Technically, the F.D.A. does not regulate the practice of medicine, so doctors are indeed able to use approved drugs and devices for unapproved purposes when they deem it appropriate.

World War I Essay -- Trench Warfare

World War I was a stalemate right from the outbreak of the war as a result of trench warfare. With the introduction of this system, a piece of land stretching from the Belgian coast, through France, and ending in Switzerland, became the venue for majority of the conflict. For almost three years, this line shifted by no more than a few hundred yards. All of this changed when the United States joined the war and prompted Germany to make an all-out drive on the Allies so as to end the war before the American Army reached full strength on the battlefield. The American Expeditionary Force allowed the Allies to take the offensive, thereby ending the static state of war that had settled on the Western Front as a result of trench warfare. The system of trench warfare had men facing each other across opposing lines dug into the ground. The purpose of digging trenches was purely a matter of survival. In a war where technology was the worst enemy, trenches were a must. Following the Battle of Somme in 1916 where casualties exceeded one million, the High Command on both sides of the war learned of the desperate need for trenches. The first trenches, as Albert Marrin describes in The Yanks are Coming, were â€Å"not mere slits in the ground.† Each trench system was composed of line upon line of trenches. Most trench systems were composed of three trenches. In case of an attack, there was usually another trench to provide defense if the forward trench was taken by the enemy. Smaller communication trenches linked each of the major trench lines (Marrin 80). The most memorable feature of any trench line was actually the land in between. This land was known as no-man’s land. No man's land varied extremely in length. There were extremes at both ends... ... of losing at which point the Americans entered the fray. The final act that broke this deadlock was the defeat of the Germans at Belleau Wood by the Americans. In doing this, they brought a sense of newfound desire and energy on the Allied part. For the Germans, the Americans represented a force to be reckoned with. The American Army brought the â€Å"fight† back to the soldiers in the trenches. Captain Lloyd Williams of the Marines was a prime example of this spirit. When asked by the French if he wanted to retreat, he replied: â€Å"Retreat? Hell we just got here.† (qtd. Antill, Dougdale-Pointon, and Rickard). As a German soldier noted, â€Å"The American . . . had nerve; we must give him credit for that; but he also displayed a savage ruthlessness. 'The Americans kill everybody' was a cry of terror. . . which for a long time stuck in the bones of our men. " (qtd. Bonk 91)

All Romances end in Marriage Essay

By this time Bathsheba was in love with Troy or believed she was. Troy also thought he was in love yet it was only infatuation. â€Å"Bathsheba loved Troy in the way that only self-reliant women love when they abandon their self-reliance† This shows that Bathsheba has given up her independence that she relied on in the past for the love of Troy. Hardy changes the character of Bathsheba slightly by falling in love with Troy as she now has given up one of her qualities that she relied on, her independence. Hardy’s readers can see that Bathsheba has changed for love as she is has wrongly fallen in love with Troy. Hardy’s readers know this is wrong and in time things will change, as this is not the cause of true love. Bathsheba and Troy eventually get married and that is when the romance begins to end. The two become less infatuated with each other and start to become bitter. When Troy, Bathsheba and her workforce are celebrating there marriage Troy gets rid of all the women and gets drunk with all the men. Meanwhile Gabriel is outside all night in the storm trying to save the harvest. Bathsheba is greatly thankful for what he has done â€Å"Thank you for your devotion a thousand times Gabriel! † Hardy shows yet again that Gabriel is the right man for Bathsheba through his loyalty, devotion and general good and decent nature. The reader knows that Bathsheba is with the wrong man and hopefully it is only a matter of time before her and Gabriel get together. When it is discovered that Fanny is dead, Gabriel is the first to look at the coffin and notices that it says â€Å"Fanny Robbin and child† Gabriel rubs out and child as he knows the child is Troy’s and he does not want her to get hurt as he cares for her. Liddy then informs Bathsheba that there is a rumour going about Weatherbury â€Å"I mean that a wicked story is got to Weatherbury within this last hour-that-that there’s two of’em in there† Bathsheba’s curiosity overwhelms her and she decides to open the coffin. Hardy then uses poetry to tell the reader that there is a baby there â€Å"A curious frame of natures work, A flow’ ret crushed in the bud, A nameless piece of babyhood,† When Troy comes in and discovers that Fanny is dead he kisses her and the baby. Bathsheba begs Troy to kiss her which shows her insecurity as she gave up her independence for him and now she wants to rely on but she knows that he still loves her. After he says â€Å"you are nothing to me† she runs out. Hardy has finally shown the true character of Troy. He is an incredibly nasty person to say this to his wife and now the reader knows it. The way he has treated Bathsheba all this time is unforgivable. Although Hardy has portrayed him as this malicious character he has proved that he did love Fanny and did not just use her for sexual pleasure. Troy eventually decides to get away from everything and fakes his own death. This is where Boldwood comes in to play again. He is still obsessively in love with Bathsheba and in doing so his farm is doing very badly. He makes a proposal to Bathsheba of marrying him in six years after Troy is officially declared dead. â€Å"Well then, do you know that without further proof of any kind you may marry again in about six years from the present- subject to nobody’s objection or blame? † Boldwood forces this offer upon Bathsheba and in the end she has to say that she will give him an answer at he Christmas party. Bathsheba. Although she believes her husband to be dead she does not have along time in which she would cease to do things due to bereavement, she carries on and is cool and level headed. This shows yet again how she is in comparison with other women in the 19th century. Normally she would be expected to bereave, it would be her role but not Bathsheba she is different and more modern than other women. During the Christmas party Boldwood asked Bathsheba for her answer and she reluctantly said yes â€Å"Very well. I’ll marry you in six years from this day if we both live,† Boldwood was delighted and he then gave her a ring, which she was forced, to where for that night. Soon after they got back to the party Hardy brought a great thrill to the novel as Troy showed up to the party, cloaked. When Troy tried to grab Bathsheba, Boldwood shot him dead. With Troy dead and Boldwood in prison the reader now knows that Hardy has left a big opening for Bathsheba’s heart. The only man left and the most decent man is Gabriel Oak. Finally Hardy gives the readers what they have wanted through out the whole novel. Gabriel asks Bathsheba to marry her and she accepts, they are soon married and the novel ends happily. Throughout this novel Hardy has shown three different types of love, obsessive, infatuation and true love. Hardy is trying to say that there are many types of love, some are not real but there is one type that is real and that is true love. True love being the type of love where you love the person for who they are not just what they look like. Hardy also shows that Bathsheba resembles a 20th century woman more than a 19th century woman. She is modern and she is very independent. Her independence is one of her main qualities along with her vanity, which slowly faded away.

How democratic was Andrew Jackson? Essay

Andrew Jackson may have been the most popular president in the history of United States. Andrew Jackson was elected as a president for his democracy and he was still getting votes from electors fifteen years after he died. But was Andrew Jackson democratic at all? He didn’t democratically act in a lot of circumstances like being partial to the poor, not paying attention to the Native Americans or not listening to Van Buren that caused a big scandal in society. Jackson was born in 1767 on the border between North and South Carolina. He was a kid with a wild streak that grew up in a poor family. His childhood was so dramatic and full of events that they made him be brave and experienced in situations. Jackson was voted for the presidency in 1828 and was reelected in 1832. He was said to create a new era of real democracy in America. But like other men, Jackson was not democratic at all and he was also claimed as behaving more like the king. First of all, Andrew Jackson was not democratic because he gave more power to the poor and seemed to be partial to them. While it was democratic that he tried to balance the power between the rich and the poor but in this circumstance, he totally took down the rich. In Document 3 which is a political cartoon, Jackson holds a veto in the left hand and a scepter in the right and tramples on the Federal Constitution and The United States Bank. It was said that Jackson was fear on the rich and powerful who may cheat the acts of government to their own selfish benefits so he vetoes the Congress’s bill to recharger the Bank in July in 1832 and removes the deposit. In fact, Jackson was doing more damage to the bank and he biased against the wealthy men in command. He may have little or no trust in what the Congress and government had deemed to be in the country best interest. In Document 5, Jackson â€Å"inflame the poor against the rich†, The rich and powerful are also People but Jackson didn’t listen to and follow their wishes. That was not democratic. In Document 2, Daniel Webster compliments that Andrew Jackson was democratic. It seemed to be contrary to his reply to Andrew’s Bank veto that Daniel totally criticizes Andrew for turning against the rich. But we can see that Webster claimed that: â€Å"Jackson was the hero of the dirt farmer.† It supported that Andrew Jackson is so partial to the poor and just stand for their sides. Jackson did have democratic ideas but his ideas didn’t actually benefit all people. This was undemocratic as it didn’t benefit all people that he took the rich down and just cared for the low class. Additionally, Jackson also acts undemocratically that he didn’t include the Native Americans. In Document 3, Andrew looks like a king although he is president because of not taking care of the Native Americans and some tribes. Since a president takes to care for all people, Jackson just cares of part of them and abuse for his power and acts only in his best interests. Based on Document 8, Jackson persuaded the Native American but actually forced them and some tribes to west of the Mississippi. It means that he kicked them out of U.S. Jackson was not democratic because he moves them to such useless land as the land was ruined and poor. Despite looking to the citizens of U.S. well, Jackson wasn’t paying attention to the suffering that he was inflicting on Native Americans. This one side shows that Jackson was not a democratic president as many people think he was. The pinnacle of being undemocratic of Jackson was in Document 7, â€Å"Jackson refused to listen. He liked Swartwout because he had been an early supporter.† Jackson appointed Samuel to the office of the collector of Port of New York instead of Buren because Swartwout was offered by people more than Van. It is contrary to his democracy of following people’s wishes that he didn’t listen to Buren. Andrew went against all reason and showed a great lack of good judgment when he appointed one of his homies who is a notorious thief. Since Samuel was in office, there was a scandal that â€Å" Swartwout absconded with $1222705.09. It was a monumental theft†¦Ã¢â‚¬  This ended up hurting the country economically and totally affected the common goods. This selfish act was a foolish one. Although Andrew Jackson, as I stated, was an undemocratic president, he was still kind and compassionate and still has little democracy. Based on Document 11, Jackson adopted a child and took care of him. He wrote letters to his wife that he would adopt an Indian son, Lynconya, â€Å"I send him to my little Andrew and I hope he will adopt him as one of our family. And the letter on December 28th, 1823, Jackson wrote that â€Å"Tell Lyncoya to read his book and be a good boy and obey you in all things.† We can see, Jackson was still democratic as he adopted an Indian boy and also buried him in the family cemetery when he died at age 14. Throughout Jackson’s life and his presidency and with the above evidence, Andrew Jackson was not a democratic president at all. He unfairly acted in several circumstances but he was also democratic and kind of adopting an Indian boy. I conclude Andrew Jackson was not as democratic as many people thought he was. His action towards people didn’t benefit everyone.

ACT Test Results How to Get and Interpret Your Results

ACT Test Results How to Get and Interpret Your Results SAT / ACT Prep Online Guides and Tips If you took the ACT recently, you’re probably eager to see how you did so you can send your scores to colleges or prepare for the next test date. But how do you get your score report, and what’s the best way to interpret your scores? In this article, I’ll go through how and when you can get your report, what’s on it, and how to get the most out of the information you’re given. How Do I Get My ACT Scores? Your multiple choice scores will be available online in your ACT Web Account about two weeks after you take the ACT.If you took Writing, those scores are available about two weeks after your multiple choice scores (so four weeks, give or take, after the test).The ACT says score reports are usually available 2-8 weeks after the test, which seems like a huge window. They're just trying to account for weird circumstances that sometimes cause scores to take longer, like an irregularity at your test center or answer documents from your test center arriving late. Barring anything out of the ordinary, you should expect to see your scores online no later than four weeks after the ACT.After this point, you can start sending them to schools. Unfortunately, there isno way to speed up the actual scoring process; you can only use rush reporting to send scores to colleges after your scores are released. What Will Be on My ACT Score Report? The first thing you’ll see on your score report is your composite score. This is the large number on the top left in the box labeled â€Å"Your ACT Scores†.You’ll also get a set of percentages with your composite score.These percentages give you your score percentile as compared to students in your state (the first bar) and in the US as a whole (the second bar). It's the percentage of students who were at or below your score level on the test. Next, you’ll see your scores broken down by section. English is split into two categories of questions: Usage/Mechanics and Rhetorical Skills Math is split into three categories of questions: Pre-Algebra/Elementary Algebra, Algebra/Coordinate Geometry, and Plane Geometry/Trigonometry Reading is split into two categories of questions: Social Studies/Sciences and Arts/Literature Science doesn’t have any breakdown of categories. It just lists one score for the whole section. For English, Math, and Reading, you'll see a score for each section and then scores for the categories beneath the sections (for Science there's only the one complete score).For each test section score and question category score you'll also see a bar that shows you your score percentile. The question category subscores can range from 1-18, and the test section scores range from 1-36 just like your full composite score.Note that the scores you see for the categories under each test section score don't necessarily add up to the section score. Your Writing score will be listed below all of these scores if you took the ACT with Writing.This score is reported on a scale of 2-12 (starting with the September 2016 ACT). There are four domain categories below the Writing score, each of which is also scored from 2-12. The ACT averages these scores to arrive at your final score out of 12. Just like with the other sections, you'll see percentile bars next to each of these scores to indicate how you compare to other students. Below your main scores, you'll see an "ELA score" and a "STEM score." The ELA score is the average of your English, Reading, and Writing (converted to a value out of 36) scores. The STEM score is the average of your Math and Science scores. Both of these are recorded on a scale of 1-36. Consult the ACT websiteto see an example of what a real score report looks like. What Do I Do With This Information From My ACT Results? So you have all these numbers, but who cares? How can they help you do better next time?If you know where your weak spots lie, it’s going to be much easier to focus your studying.Here are a couple examples of actions you might take based on what you see on your score report: Case #1: You Aced Algebra But Missed a Lot of Trigonometry Questions This indicates that you have a content-based problem with trigonometry. Maybe you didn’t know all the formulas or you're not familiar with the best strategies to solve these types of problems.Review all the formulas you need to know for ACT Math as related to trigonometry. Also review what’s tested on ACT Math, and make sure you’re familiar with all the material. If you see something you feel shaky on, try some practice questions for that topic.Look intothese strategies for improving your math performance as well. Case #2: You Did Well on English, But your Writing Score Was Low The essay can be one of the toughest aspects of the ACT, especially because it comes at the end of the test when you’re tired already. Though the ELA subscore doesn't affect your overall ACT score, many top colleges are still interested in your performance on the essay. If you had trouble with the essay, take a look at these tips for improving your score.Since you did well on the English section, you probably don’t have a problem with grammar and sentence structure. You might just need to work on organizing your thoughts better overall and providing better examples to support your argument. Case #3: You Struggled with Science and Reading If you had issues with these sections, it probably means you need to work on reading passages more efficiently and interpreting them correctly.Check out these strategies for bothscience passages and reading passages.The Science and Reading sections actually require similar skills, namely skimming over information and making fast-paced judgments about the content. If you think the time constraints caused you to miss questions, review these strategies for time management on both sections. Experiment with different strategies for approaching ACT science passages...heh A Final Word on Score Reports Your score report is a helpful study tool that will give you more information about areas on the test where you need to make improvements.It might also be a good idea to order Test Information Release for the ACT, which provides a more in-depth look at your scores and the specific questions you missed. Read more about this service here. Compare your score report to your target scores so you can see how much you need to study before the next test! What's Next? If you're trying to figure out when you should take the ACT again, use this guide to find out which test date is right for you. Check out these study plans to get an idea of how you might plan out your prep in advance of the next test date. Frustrated with your score? Learn how to get a perfect 36 on the ACT, and check out these more detailed guides on doing well on ACT English, Math, Reading, and Science. Want to improve your ACT score by 4+ points? Download our free guide to the top 5 strategies you need in your prep to improve your ACT score dramatically. Have friends who also need help with test prep? Share this article! Tweet Samantha Lindsay About the Author Samantha is a blog content writer for PrepScholar. Her goal is to help students adopt a less stressful view of standardized testing and other academic challenges through her articles. Samantha is also passionate about art and graduated with honors from Dartmouth College as a Studio Art major in 2014. In high school, she earned a 2400 on the SAT, 5's on all seven of her AP tests, and was named a National Merit Scholar. Get Free Guides to Boost Your SAT/ACT Get FREE EXCLUSIVE insider tips on how to ACE THE SAT/ACT. 100% Privacy. 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Free Essays on Aviation Finance

In the past few years, we have been able to see the near demise of some of the world’s largest airlines. However at the other end of the table sit such sound companies as Jet Blue and Southwest. The mere existence of such companies proves that airline carriers can be viable business entities. Troubled airlines such as United Airlines and American Airlines can see brighter skies in the future, by minimizing costs and maximizing revenues. Nevertheless, lowering costs and raising revenues cannot effectively fix the struggling airlines problems if the airlines are not able to operate in a free market environment. The airline industry is a service industry. The airlines are in the business of transporting people and their belongings as well as products. The major characteristics of the industry include the following: capital intensive, high cash flows, labor intensive, highly unionized, and seasonal. These characteristics are the cause of the industry’s then profit margin. In fact â€Å"airlines, through the years, have earned a net profit between one and two percent, compared to an average of above five percent for U.S. industry’s as a whole†. Due to the industry’s thin profit margin, it comes as no surprise that the history of airlines has been a rocky one. The airline industry has been for the most part profitable for the last sixty years. However a thin profit margin has been a major problem throughout the industry’s history. The majority of the airlines are unable to profitably deal with extreme economic events such as depression, recession, war, and of course the September 11 attacks. Furthermore they are unable to profitably deal with changes in the industry such as, the government deregulation that occurred in the late 70’s and early 80’s. The results of such events are larger than average declines in profit compared to higher profit margin industries. This fact can be seen in the annual reports publish... Free Essays on Aviation Finance Free Essays on Aviation Finance In the past few years, we have been able to see the near demise of some of the world’s largest airlines. However at the other end of the table sit such sound companies as Jet Blue and Southwest. The mere existence of such companies proves that airline carriers can be viable business entities. Troubled airlines such as United Airlines and American Airlines can see brighter skies in the future, by minimizing costs and maximizing revenues. Nevertheless, lowering costs and raising revenues cannot effectively fix the struggling airlines problems if the airlines are not able to operate in a free market environment. The airline industry is a service industry. The airlines are in the business of transporting people and their belongings as well as products. The major characteristics of the industry include the following: capital intensive, high cash flows, labor intensive, highly unionized, and seasonal. These characteristics are the cause of the industry’s then profit margin. In fact â€Å"airlines, through the years, have earned a net profit between one and two percent, compared to an average of above five percent for U.S. industry’s as a whole†. Due to the industry’s thin profit margin, it comes as no surprise that the history of airlines has been a rocky one. The airline industry has been for the most part profitable for the last sixty years. However a thin profit margin has been a major problem throughout the industry’s history. The majority of the airlines are unable to profitably deal with extreme economic events such as depression, recession, war, and of course the September 11 attacks. Furthermore they are unable to profitably deal with changes in the industry such as, the government deregulation that occurred in the late 70’s and early 80’s. The results of such events are larger than average declines in profit compared to higher profit margin industries. This fact can be seen in the annual reports publish...

Medieval Clothing Styles by Region and Period

Medieval Clothing Styles by Region and Period In Europe,  Ã¢â‚¬â€¹medieval clothing varied according to the time frame as well as the region. Here are some societies (and segments of society) whose clothing styles are especially evocative of their cultures. Clothing of Late Antiquity, 3rd- to 7th-Century Europe Traditional Roman garb consisted largely of simple, single pieces of fabric that were carefully wrapped to cover the body. As the Western Roman Empire declined, fashions were influenced by the sturdy, protective garments of Barbarian peoples. The result was a synthesis of trousers and sleeved shirts with cloaks, stolas, and palliums. Medieval clothing would evolve from  late antique garments and styles. Byzantine Fashions, 4th- to 15th-Century Eastern Roman Empire People of the  Ã¢â‚¬â€¹Byzantine Empire inherited many of the traditions of Rome, but fashion was also influenced by the styles of the East. They abandoned wrapped garments for long-sleeved, flowing tunicas and dalmaticas that often fell to the floor. Thanks to Constantinoples standing as a center of trade, luxurious fabrics like silk and cotton were available to the richer Byzantines. Fashions for the elite changed frequently over the centuries, but the essential elements of costume remained fairly consistent. The extreme luxury of Byzantine fashions served as a counterpoint to most European medieval clothing. Viking Apparel, 8th- to 11th-Century Scandinavia and Britain Scandinavian and Germanic peoples in northern Europe dressed for warmth and utility. Men wore trousers, shirts with tight-fitting sleeves, capes, and hats. They often wore leg wraps around their calves and simple shoes or boots of leather. Women wore layers of tunics: linen under woolen overtunics, sometimes kept in place at the shoulders with decorative brooches. Viking clothing was often decorated with embroidery or braid. Aside from the tunic (which was also worn in Late Antiquity), most Viking garb had little influence on later European medieval clothing. European Peasant Dress, 8th- to 15th-Century Europe and Britain While the fashions of the upper classes were changing with the decade, peasants and laborers wore useful, modest garments that varied little over the centuries. Their outfits revolved around a simple yet versatile tunic - longer for women than for men - and were usually somewhat dull in color. High Medieval Fashion of the Nobility, 12th- to 14th-Century Europe and Britain For most of the early Middle Ages, the clothing worn by men and women of the nobility shared a basic pattern with that worn by the working classes, but was generally made of finer fabric, in bolder and brighter colors, and at times with additional decoration. In the late 12th and 13th century, to this plain style was added a surcoat, probably influenced by the tabard worn by crusading knights over their armor. It wasnt until the mid-14th century that designs really began to change noticeably, becoming more tailored and increasingly elaborate. It is the style of the nobility in the high Middle Ages that most people would recognize as medieval clothing. Italian Renaissance Style, 15th- to 17th-Century Italy Throughout the Middle Ages, but especially in the later Middle Ages, Italian cities such as Venice, Florence, Genoa, and Milan flourished as a result of international commerce. Families grew wealthy trading in spices, rare foods, jewels, furs, precious metals and, of course, cloth. Some of the finest and most sought-after fabrics were produced in Italy, and the extensive disposable income enjoyed by the Italian upper classes was spent lavishly on more and more ostentatious outfits. As costume evolved from medieval clothing to Renaissance fashion, the outfits were captured by artists who painted the portraits of their patrons as had not been done in earlier times. Sources Piponnier, Francoise, and Perrine Mane, Dress in the Middle Ages. Yale University Press, 1997, 167 pp. Kà ¶hler, Carl, A History of Costume. George G. Harrap and Company, Limited, 1928; reprinted by Dover; 464 pp. Norris, Herbert, Medieval Costume and Fashion. J.M. Dent and Sons, Ltd., London, 1927; reprinted by Dover; 485 pp. Jesch, Judith, Women in the Viking Age. Boydell Press, 1991, 248 pp. Houston, Mary G., Medieval Costume in England and France: The 13th, 14th and 15th Centuries. Adam and Charles Black, London, 1939; reprinted by Dover; 226 pp.

Organisations & Behaviour Learning Organisations Essay

Organisations & Behaviour Learning Organisations - Essay Example A learning organisation intentionally designs the structures and strategies in order to enhance and maximise the learning of its employees. (Dodgson, 1993) With the changing environment of business and advancing technology the notion of the Learning organisations has gained much more importance. Learning has become an important characteristic of an organisation in order to compete in the global business. Learning is a volatile and dynamic concept through which the process of updating in an organisation takes place. With the growing size of the corporations and continuous innovations in the field of technology the individual learning has transformed to the notion of the organisational learning. The notion of learning plays an important part in the progress of an individual just like that the learning on the organisational level plays an important part in the growth of an organisation. The organisational group of people can define the organisational learning as the sum of the learning activities of the individual, which takes the shape of combined effort. (Dodgson, 1993; Fiol & Lyles, 1985). An organisational learning program should be designed in the way that it is not lost when the members of the organisation leave the organisation. ... ive environment of the business in today's high pace changing business environment enhancing the learning capabilities of business is the solution of half of the problems. (Prahalad & Hamel, 1994). Equally important is the creation of an unlearning organisation which essentially means that the organisation must forget some of its past. Thus, learning occurs amidst such conflicting factors (Dodgson, 1993). Most of the leading companies of the world like Shell were among the first to embrace the notion of learning. In Shell Arie de Geus described learning as the only strategy to compete effectively. Hence learning organisation can be defined as "The essence of organisational learning is the organisation's ability to use the amazing mental capacity of all its members to create the kind of processes that will improve its own" (Dixon, 1994) "A Learning Company is an organisation that facilitates the learning of all its members and continually transforms itself" (Pedler, Burgoyne & Boydell, 1991) "Organisations where people continually expand their capacity to create the results they truly desire, where new and expansive patterns of thinking are nurtured, where collective aspiration is set free, and where people are continually learning to learn together" (Peter Senge, 1990) The following are the important characteristics of the learning organisations: Learning organisations adopts the external environments. They are flexible and continue the process of change. Depicts the combination of individual and collective learning. Keeps on learning with the outcomes. Learning can be done in two ways. 1) Single loop 2) Double loop In single loop learning people learn in a way prescribed to them by the organisation. In double loop learning people, people not only learn in a

Departmentalization Essay Example | Topics and Well Written Essays - 2500 words

Departmentalization - Essay Example The importance of the departmentalization is to enhance the performance of the employees and to implement successful planning by the management to encourage efficiency. The significance of departmentalization is to improve efficiency of the organization through specifications. The efficiency and responsibility increases with the implementation of departmentalization, which facilitates the emotion of autonomy among the managers. Due to this form of management structure, every department has a manager and the responsibility is hence divided in the departments. The facility of appraisal, budget preparation and the supervision become easier and more effective after the implementation of the departmentalization (Anbuvelan 103-106). The purpose of the departmentalization is to ensure smooth administration at every level. It is the process of dividing the large organization into small functional groups for proper flexible administrations. The use of this form of organizational structure inc reases the efficiency of the employees. This makes the executives more responsible and helps in increasing the prestige and skills of the departmental heads. ... The study also explores the different forms of departmentalization used by different companies in the global context. TYPES OF DEPARTMENTALIZATION Departmentalization is the procedure of dividing the large organization into various small units. Every department has their own manager and specific work to increase the efficiency and its effectiveness. There are six forms of departmentalization with the aim to increase efficiency in the work environment. Functional Departmentalization. In this form of departmentalization, the grouping is done on the basis of the functional aspects. The grouping is done on the basis of skill and knowledge. The group or departments formed generally include the accounting, marketing and Information Technology (IT). This form of departmentalization is present in every organization. The basic organizational functions are done in this form of departments and through this form the nature of the business can be realized. In this departmentalization form, people with similar skills and knowledge perform the tasks and hence the focus becomes narrow which increases the efficiency level (Mahida 4-5). Advantages In this approach, the level of efficiency increases as people with similar skills work together and the knowledge shared enables to derive decisive benefits for the organization. Functional departmentalization increases the level of analysis because of the in-depth knowledge of the people in a department. It helps in facilitating easier coordination within the department and the organization. It also reduces the cost of repetition and minimizes the need for training (Pride, Hughes and Kapoor 196-197). Disadvantages In terms of disadvantages, it is at times observed that

Making Sense of Strategy II Essay Example | Topics and Well Written Essays - 3000 words

Making Sense of Strategy II - Essay Example In order to maintain a successful brand image of an organization in international perspectives are to offer high concentration over the factor conditions. The prime domestic factor conditions of the industry of telecommunication might be capital and quality of infrastructure. This is because, it is the capital or the revenue that helps an organization operating in this segment i.e. telecom to amplify it is growth and expansions in other international nations or countries. Similarly, the organization of Oman Tel invested a huge amount of capital or revenue in order to develop it is 3G and 4G network connections. Other than this, by investing a huge amount of revenue worth OMR 116 million by the organization of Oman Tel proved extremely effective for it to expand it is network connections in numerous rural as well as developed countries of the entire world. As a result of which, the organization of Oman Tel became successful in positioning it is 3G and 4G network among the target custo mers of Oman. As a result, the brand value and market share of the broadband connections increased by 61.6 percent as compared to many other rival contenders. In addition, the organization of Oman Tel also decided to offer high-ended services to the target customers so as to amplify it is equity and uniqueness in the market of Oman. Along with this, the organization of Oman Tel implemented low tariff plans in order to increase it is range of customers and to retain the existing ones so as to amplify it is competitive advantage and sustainability in the market among many other rival contenders (OmanTel, 2014). In addition to this, the organization of Oman Tel implemented the plan of unlimited usage in order to enhance it is position and reputation in the market of Oman among it is target segments. Due to which, the organization of Oman Tel became successful in

The Phenomenon Of Terrorism Research Paper Example | Topics and Well Written Essays - 1500 words

The Phenomenon Of Terrorism - Research Paper Example Body Causes of terrorism Ethnicity and separation are two factors that significantly contribute to terrorism in different countries. Individuals from nations that are not united tend to cause trouble to other nations as a way of finding the key cause of disagreements to their own nations (Bjorgo,  2005). Separation among different nations can also be explained by political and religious differences. This also brings in the issue of racism in a country. When a country has some form of inequality, it will definitely have many terrorism cases because people will not be united. For instance, in the year 1990, racism in the United States caused terrorism cases to increase because, each group wanted to defend itself from being attacked by the other. Separation in the community can also be explained from a different point of view where there is a group of persons in the society that are dissatisfied (Crenshaw, 1981). Some individuals in the community may feel that they are not being given equal rights as other individuals. Thus, they might engage in terrorism acts in order to have such rights too. Therefore, inequality in the society can fuel terrorism. This is because; inequality and unfairness causes feelings of depression among people. Consequently, it causes individuals to act out of frustration and anger (Al-Thagafi & Army War College (U.S.), 2008). Terrorism can also be caused by the lack of or unequal opportunities for political participation (Crenshaw, 1981). When political opportunities are only available to a certain group of people in the society, then other individuals will use terrorism acts to obtain political power. This is a case where by politicians who obtain power in the wrong... Some individuals in the community may feel that they are not being given equal rights as other individuals. Thus, they might engage in terrorist acts in order to have such rights too. Therefore, inequality in the society can fuel terrorism. This is because; inequality and unfairness cause feelings of depression among people. Consequently, it causes individuals to act out of frustration and anger (Al-Thagafi & Army War College (U.S.), 2008). Terrorism can also be caused by the lack of or unequal opportunities for political participation (Crenshaw, 1981). When political opportunities are only available to a certain group of people in the society, then other individuals will use terrorist acts to obtain political power. This is a case where by politicians who obtain power in the wrong manner end up being killed in terrorism. When individuals are not in support of the governance of a country, they tend to engage in terrorist acts in order to eliminate the individuals in leadership. This can also be referred to as anti-democracy. When there are a large number of weaknesses in a democratic government, terrorism is bound to increase. This is because; democracy involves a lot of openness, which makes terrorists be in possession of information that they can use to plan terrorist attacks. Effects of Terrorism Terrorism is normally directed at disrupting and disorganizing government procedures in a country. It weakens and damages the operations of leadership in a country (Houle, 2005).

Effective Team and Performance Management Essay - 7

Effective Team and Performance Management - Essay Example P.1). Tuckman theory of team formation and development is the most acknowledged model of team development and occurs in four stages which are forming, storming, norming and performing (Johnson 2010, P. 17). After the performing stage Tuckman developed another stage and named it as the adjourning stage (Edison 2008, P. 14). Meredith Belbin’s team theory analysis the roles played by team members depending on their characteristics and behaviors as well as interpersonal styles. Team performance is affected by its characteristics in regards to size, team norms, team cohesion, management styles, conflict resolutions approaches and feelings among the team members towards each other. Effective management is important for the success of the team. An effective team manager adopts different management styles depending on the arising situation in the workplace (Efere, 2003). There are several team management styles namely authoritarian style, democratic style, laissez-Faire Style, paterna listic, concertive style among others which a manager or a company can adopt (Efere, 2003). This paper will critically evaluate theories on team dynamics, formation, conflict resolutions, factors affecting team performance and offer recommendations for the management to improve teams in Electron Company if adopted. Introduction An effective team may is able to move to and from one stage to another. A company may change its strategy and therefore form different teams. Electron Company changed its management structure and team management to increase performances. Electron is a manufacturing company dealing with telecommunication components and is situated in United Kingdom, established in 1997 as a department and sold out ten years later in 2007 as the original company opted to subcontract its manufacturing department and that is why up to today the company is still the leading client of electron. The management structure was not changed. However the company did not perform as expecte d and this necessitated change in its production practices by escalating productivity, improved client services and improved team performance. A new management approach was introduced to help the different teams achieve productivity objectives in a period of two months and in addition the teams that were to meet their objectives, to all members were paid additional benefits. In the restructured format, new employees were employed on temporary basis while the old employees were distributed to all the teams to help the new members adapt into the company. The teams had the authority to establish their working norms which they would follow and the new team members we supposed to comprehend and follow the teams’ norms and values and therefore the teams were affirming concertive control on the newly employed. Team formation In an organization employees of a specific department work as a team or in some cases teams are established to perform a specific task. Evaluations of the teams are conducted periodically to determine their performance or set new goals after the team is formed it takes time to grow and mature to an efficient team. Several theories explain team dynamics and development and most sociologist point to relationship and personal characteristics of the members involved (Nazzaro and Strazzabosco 2009). Tuckman’s model of team development Tuckman's group development model pays

COMPANY LAW Essay Example | Topics and Well Written Essays - 2500 words

COMPANY LAW - Essay Example And when this problem occurs, Black Books may find itself enmeshed in huge debts owing to corporate inactivity; (iii) loss of control on the company—this means that in the event of incurring huge debts due to poor performance, the lenders may request that the current management at Black Books be replaced by receivership or administration that are external and has little knowledge of how Black Books has been run (Mead and Sagar, 2006). The major problem associated with incurring huge debts or going insolvent is that it may destroy a company’s brand image that had been developed for years. And if this condition occurs or left to persist, it would be difficult for Black Books to regain the loyalty of its long- 2 time customers who may have begun to boycott the company’s books for another one (Omar, 2004). However, the main advantage of sourcing operating capital through loan or borrowing from lenders is that Black Books could claim tax relief on the interests payabl e to service the loan (Mead and Sagar, 2006). ... But using share capital appears safe for Black Books (if the company has chosen this method earlier on) because there would be no fear of going bankrupt owing to the restrictions on the utilization of Black Books’ assets placed under the lenders as collateral securities. Hence, Black Books can continue to operate and protect its brand image from being sullied due to insolvency and the take-over of the company’s administration by a new set of managers, who may lack adequate information about the true state of the company (Omar, 2004). 3 (ii) Black Books is expected to create debentures, which are the documents detailing the terms of borrowing capital loan from the lenders. Black Books has also indicated in the debentures some floating charges on some or all of its assets so as to fulfill the requirements stipulated by the lenders. However, some formalities must be strictly followed in order to draw up the appropriate debentures necessary for Black Books to get the loan. And each of the formalities has legal consequences as explained in the series of processes below: (a) Black Books approaches Lender to borrow ?500,000; the formality here is offering a legal mortgage of the company’s land as a security for the loan in favour of the Lender. This entails that the Lender has powers on the property—it could either restrict Black Books’ access to the land or sell it off when the company failed to pay the loan interests (Dakin et al., 2002). (b) Black Books wants to issue a first floating charge over the company's assets to the extent of ?100,000 in favour of the company's major trade creditor, Supplier, and include a "negative pledge" clause—the essence of a negative clause is to give the

Effective Team and Performance Management Essay - 7

Effective Team and Performance Management - Essay Example P.1). Tuckman theory of team formation and development is the most acknowledged model of team development and occurs in four stages which are forming, storming, norming and performing (Johnson 2010, P. 17). After the performing stage Tuckman developed another stage and named it as the adjourning stage (Edison 2008, P. 14). Meredith Belbin’s team theory analysis the roles played by team members depending on their characteristics and behaviors as well as interpersonal styles. Team performance is affected by its characteristics in regards to size, team norms, team cohesion, management styles, conflict resolutions approaches and feelings among the team members towards each other. Effective management is important for the success of the team. An effective team manager adopts different management styles depending on the arising situation in the workplace (Efere, 2003). There are several team management styles namely authoritarian style, democratic style, laissez-Faire Style, paterna listic, concertive style among others which a manager or a company can adopt (Efere, 2003). This paper will critically evaluate theories on team dynamics, formation, conflict resolutions, factors affecting team performance and offer recommendations for the management to improve teams in Electron Company if adopted. Introduction An effective team may is able to move to and from one stage to another. A company may change its strategy and therefore form different teams. Electron Company changed its management structure and team management to increase performances. Electron is a manufacturing company dealing with telecommunication components and is situated in United Kingdom, established in 1997 as a department and sold out ten years later in 2007 as the original company opted to subcontract its manufacturing department and that is why up to today the company is still the leading client of electron. The management structure was not changed. However the company did not perform as expecte d and this necessitated change in its production practices by escalating productivity, improved client services and improved team performance. A new management approach was introduced to help the different teams achieve productivity objectives in a period of two months and in addition the teams that were to meet their objectives, to all members were paid additional benefits. In the restructured format, new employees were employed on temporary basis while the old employees were distributed to all the teams to help the new members adapt into the company. The teams had the authority to establish their working norms which they would follow and the new team members we supposed to comprehend and follow the teams’ norms and values and therefore the teams were affirming concertive control on the newly employed. Team formation In an organization employees of a specific department work as a team or in some cases teams are established to perform a specific task. Evaluations of the teams are conducted periodically to determine their performance or set new goals after the team is formed it takes time to grow and mature to an efficient team. Several theories explain team dynamics and development and most sociologist point to relationship and personal characteristics of the members involved (Nazzaro and Strazzabosco 2009). Tuckman’s model of team development Tuckman's group development model pays

Unit 4 Discussion Social Problems Research Paper

Unit 4 Discussion Social Problems - Research Paper Example In my view deterrence, which is the prospect of unpleasant punishment that will put people off with the idea of committing that crime (Corbett, 2005), seems to best fit upon the criteria and objective of punishment. Deterrence helps achieve the objective of punishing the offender of the crime that has been committed and also may help avoid future such action. The condition that lies with it is that it should be effective enough. In my view, the most ineffective punishment is incapacitation. Incapacitation may be severe in terms of the punishment the offender is entitled to receive plus it may infuriate the offender such so he would increase the severity of crimes after being released, in order to retaliate. Juveniles get involved in crime due to drug addiction, bad company, peer pressure, bad relations with parents, and lack of supervision (Saminsky, 2010). Juveniles cannot be punished directly as opposed to males, as most of them do not know the severity of the crimes they have committed. They have to be treated and rehabilitated (Samaha, 2006), so they may lead a better

Hobbes VS. Locke VS. Rousseau Essay Example for Free

Hobbes VS. Locke VS. Rousseau Essay â€Å"I am at the point of believing, that my labor will be as useless as the commonwealth of Plato. For Plato, also is of the opinion that it is impossible for the disorders of the state ever to be taken away until sovereigns be philosophers . . . I recover some hope that one time or other this writing of mine may fall into the hands of a sovereign who will consider it for himself, for it is short, and I think clear. † -The Monster of Malmesbury (Thomas Hobbes), Leviathan1 Thomas Hobbes was born at Westport near Malmesbury in Wiltshire, England. 2 A wealthy uncle paid for his education and sent him to Magdalen Hall, Oxford. 3 Hobbes lived at a time of immense intellectual excitement, and the universities of his day were far from being at the cutting-edge of intellectual advance. 4 The Oxford curriculum still consisted largely of scholastic logic and metaphysics, which he regarded as sterile pedantry and for which he had nothing good to say. 5 Leaving university with a degree in scholastic logic and, it has been said, several more degrees of contempt for Aristotle in particular, and universities in general, Hobbes obtained a post as tutor to the Earl of Devonshire. 6 He travelled widely with the Duke, moving in increasingly aristocratic circles and even meeting the celebrated Italian astronomer Galileo, in 1636. 7 Hobbes also met another important figure, Sir Francis Bacon. Francis Bacon was a philosopher who rejected the Aristotelian logic and system, which basically was a speculative system, started out from some major assumptions and through deductions developed his philosophical system. 8 Thomas Hobbes has a more cynical and realistic, view of human nature than the Greeks. 9 Whilst he agrees that people have regard for their self-interest, there is little else Hobbes will accept from the ancients. 10 Hobbes was considered by many of his contemporaries to be, if not actually an atheist, certainly a heretic. 11 Indeed, after the Great Plague of 1666, in which 60,000 Londoners died, and the Great Fire straight afterwards, a parliamentary committee was set up to investigate whether heresy might have contributed to the two disasters. 12 The list of possible causes includes Hobbes’ writings. 13 Hobbes’ books are a strange mixture of jurisprudence, religious enthusiasm, and political iconoclasm. 14 Hobbes’ political theory, then is that of someone who experienced both the English Civil War and the Scientific Revolution of the seventeenth century. 15 This fact is important to our understanding of it. 16 He formulated his political ideas several times, but it is in Leviathan that they find their most complete and influential statement. 17 His approach to politics is self-consciously scientific. 18 His technique of enquiry is delivered partly from the ‘resolutive-compositive’ method associated with Galileo and Bacon, and partly from the deductive reasoning that had so impressed him in Euclid. 19 If we are to arrive at a sound understanding of politics, we must first analyze or resolve social wholes into their smallest component parts: namely, individual human beings. 20 Then, having studied the properties and behavior of those parts in isolation, we can deduce from them, as it were from first principles, rational conclusions about social and political organization. 21 He breaks down (by analysis) social phenomena into their basic constituents, and only then synthesizes these to produce a new theory. 22 It is this technique, as much as his theory of power as the motivating spring of mankind, that makes Hobbes a distinctly modern thinker. 23 His materialism is central to his account of human behavior. 24 The body of each human being is, he thinks, only a complex mechanism, somewhat like a clock. 25 Hobbes has a mechanistic Weltanschauung. We are bodies in constant motion. 26 He seems in other words, to have a kind of materialistic psychology in which human behavior exhibits the same, as it were, mechanical tendencies as billiard balls that can be understood as obeying, again, geometric or causal processes of cause and effect. 27 Before we proceed to his account of the state of nature, we will explore first some of his important ideas. First, is his skeptical view of knowledge. Hobbes was obsessed with the question about what can I know or, maybe put a different way, what am I entitled to believe, and there are many passages in Leviathan that testify to Hobbes’ fundamentally skeptical view of knowledge. 28 He is a skeptic not because he believes that we can have no foundations for our beliefs, but he is skeptic in the sense that there can be no, on his view, transcendent of nonhuman foundations for our beliefs. 29 We cannot be certain, he thinks, of the ultimate foundations of our knowledge and this explains you may have wondered about this, this explains the importance he attributes to such things as naming and attaching correct definitions to things. 30 Knowledge, in other words, is for Hobbes a human construction and it is always subject to what human beings can be made to agree upon and that skeptical view of knowledge or at least skeptical view of the foundation of knowledge has far reaching consequences for him. 31 This argument of Hobbes resembles the thesis of Berger and Luckmann’s book. The ongoing process of objectivation-externalization-internalization to construct, reconstruct, and deconstruct the world. In other words, knowledge and human reality is ‘socially constructed’. 32 If all knowledge, according to Hobbes, ultimately rests on agreement about shared terms, he infers from that our reason, our rationality, has no share in what Plato or Aristotle would have called the divine Noos, the divine intelligence. 33 Our reason does not testify to some kind of inner voice of conscience or anything that would purport to give it some kind of indubitable foundation. 34 Such certainty as we have about anything is for Hobbes always provisional, discovered on the basis of experience and subject to continual revision in the light of further experience, and that again experiential conception of knowledge. 35 Next, is his idea of the laws of nature. Fear is the basis, even of what Hobbes called the various laws of nature. 36 The laws of nature for Hobbes are described as a precept or a general rule of reason that every man ought to endeavor peace and it is out of fear that we begin to reason and see the advantages of society; reason is dependent upon the passions, upon fear. 37 The natural laws for Hobbes are not divine commands or ordinances, he says, but they are rules of practical reason figured out by us as the optimal means of securing our well-being. 38 Ignorance of the law of nature is no excuse. 39 According to Prof. Bacale-Ocampo LlB, there are two doctrines of the natural law: everyone must seek peace and follow it, and man being able, if others were too. 40 Hobbes also said that there can be no unjust laws. There are two reasons for this proposition, according to Prof. Bacale-Ocampo LlB: law precedes justice, and the sovereign is the embodiment of all the people’s rights. 41 This argument justifies Hobbes’ defense of the absolute and authoritarian power of his sovereign. The power of the sovereign, Hobbes continually insists, must be unlimited. 42 This notion also resembles Art. XVI, Sec. III of the 1987 Philippine Constitution, that, â€Å"The State may not be sued without its consent. † In a very real sense, a suit against the State by its citizens is, in effect, a suit against the rest of the people represented by their common government – an anomalous and absurd situation indeed. 43 Now, let’s go to his notion of the state of nature. The state of nature, a shocking phrase calculated to arouse the wrath of the Church, directly conflicting with the rosy biblical image of Adam and Eve in the Garden of Eden before the Fall. 44 Hobbes thinks the ‘human machine’ is programmed to direct its energies selfishly. 45 He doubts if it is ever possible for human beings to act altruistically, and even apparently benevolent action is actually self-serving, perhaps an attempt to make them feel good about themselves. 46 Hobbes tells us, â€Å". . . in the first place, I put for a general inclination of all mankind, a perpetual and restless desire of Power after Power, that ceaseth only in Death. †47 The desire for power is the cause of human strife and conflict. 48 Finally, Hobbes most quoted statement, that in the state of nature, â€Å". . . there is no place for Industry; because the fruit thereof is uncertain: and consequently no Culture of the Earth; no Navigation, nor use of the Commodities that may be imported by Sea; no Commodious Building; no instruments of moving, and removing such things as require much force; no knowledge of the face of the Earth; no account of Time; no Arts; no Letters; no Society; and which is worst of all, continual fear, and danger of violent death; And the life of man, solitary, poor, nasty, brutish, and short. †49 The state of nature is simply a kind of condition of maximum insecurity. 50 Hobbes continues, â€Å"Hereby it is manifest, that during the time men live without a common power to keep them all in awe, they are in that condition which is called War; and such a War, as is of every man against every man . . . the nature of war, consisteth not in actual fighting; but in the known disposition thereto, during all the time there is no assurance to the contrary. †51 There are three principle causes of quarrel. The first is competition, for gain; the second is diffidence and a compulsion for safety; whilst the final one is the compulsion for glory, and for reputation. 52 Yet they all precipitate violence. 53 Hobbes tells us, â€Å"The first use violence, to make themselves Masters of other men’s persons, wives, children, and cattle; the second, to defend them; the third, for trifles, as a word, a smile, a different opinion, and any other sign of undervalue either direct in their Persons, or by reflection in their Kindred, their Friends, their Nation, their Profession, or their Name. †54 Hobbes also asks the readers, â€Å"Let him, the reader, therefore ask himself, when taking a journey he arms himself and seeks to go well accompanied. When going to sleep, he locks his doors even when in his house, and even when in his house he locks his chest and this, when he know, he says, there be laws and public officers armed to avenge all injuries shall be done to him . . . Does he not therefore as much accuse mankind by his action as I do by my words? †55 In short, the members of the Hobbesian state of nature employs the classic prisoner’s dilemma. The strategic interests of the two individuals are antithetical to each other, and that keeps them from forming a social solidarity that would be best for them altogether. 56 The prisoner’s dilemma is analogous to a social world in which public goods would be quite valuable to have, but in which individuals would lose something from contributing to the public good as long as other people do not. 57 There has to be an assurance that the other side will live up to the bargain; but there is no way of knowing that, and in fact one can figure out that other people will act just like oneself. 58 Whether one assumes that the other person is ultimately selfish, or merely distrusting, the outcome is the same. 59 Rational selfish individuals dealing with other rational selfish individuals will never sacrifice anything to the public good, since it would be a waste. 60 That is what makes the situation a dilemma. 61 Hobbes constructed his state of nature, using logic, not using historical data. The state of nature, for him, is rather a kind of thought experiment after the manner of experimental science. 62 Hobbes is the, again, the great founder of what we might call, among others, is the experimental method in social and political science. 63 How can we escape the horror of the Hobbesian state of nature? By establishing a sovereign by means of a social contract. He would understand (1) that it is rationally necessary to seek peace; (2) that the way to secure peace is to enter into an agreement with others not to harm one another; and (3) that having entered into such an agreement, it would be irrational, in the sense of self-defeating, to break it for as long as the others kept it. 64 By this chain of reasoning, society would be created. 65 It would be created by an agreement – a ‘compact’, as Hobbes calls it – made by individuals no one of whom has interest in anyone else’s good per se, but each of whom realizes that his own good can be secured only by agreeing not to harm others in return for their agreement not to harm him. 66 But, there must be an enforcer, because Hobbes argues that, â€Å"Covenants without the sword are but words, and of no strength to secure a man at all. †67 So the people will have to, â€Å"Confer all power and strength upon one Man, or upon one assembly of men, that may reduce all their wills, by plurality of voices, unto one Will . . . This is more than Consent, or Concord; it is a real Unity of them all, in one and the same Person, made by Covenant of every man with every man . . . that Great Leviathan, the Commonwealth, and it comes about when either one man by War subdueth his enemies to his will, or when men agree amongst themselves, to submit to some Man, or Assembly of men, voluntarily, on confidence to be protected by him against all others. †68 The sovereign is created by, but not a party to, the compact. 69 He therefore cannot be got rid of because he is in reach of the compact. 70 If he could be, his power would not, after all, be sovereign. 71 Hobbes remains one of the most impressive and influential of English political theorists. 72 He is also, though he several times twits himself on his own timidity, a writer of considerable intellectual courage, who expressed unpopular views at a time when it was dangerous – mortally dangerous, indeed to do so. 73 He also â€Å"provides an antidote to the high-minded reasoning of the schoolmen and indeed the Ancients. †74 Starting from a pragmatic assessment of human nature, he strengthens the case for a powerful political and social apparatus organizing our lives. 75 And with his interest in the methods of geometry and the natural sciences, he brings a new style of argument to political theorizing that is both more persuasive and more effective. 76 But from Hobbes we also obtain a reminder that social organization, however committed to fairness and equality it may be intended to be, being motivated by a struggle between its members, is also inevitably both authoritarian and inegalitarian. 77 Virtually all subsequent attempts to treat politics and political behavior philosophically have in some sense had to take Hobbes into account. 78 â€Å"Though the water running in the fountain be everyone’s, yet who can doubt but that in the pitcher is his only who drew it out? † -John Locke, Second Treatise79 John Locke was born into a Puritan family in Somerset, England. 80 His father was a country lawyer who raised a troop of horse and fought on the parliamentary side in the Civil War. 81 Locke went up to Christ Church, Oxford, in 1652. 82 Like Hobbes before him, Locke found the old fashioned Scholastic curriculum uncongenial, though his association with Christ Church was to last, with interruptions, for more than thirty years. 83 He became a senior student – that is, a Fellow – in 1659. 84 In 1667 he became medical adviser and general factotum of Anthony Ashley Cooper, created first Earl of Shaftesbury in 1672. 85 When Shaftesbury was appointed Lord Chancellor in 1672, Locke became his secretary. 86 Earl Shaftesbury went on to three notable political achievements: he led the opposition to Charles II, he founded the Whig Party, the forerunner of the Liberals, and he pushed Locke into politics. 87 John Locke is a kind of ‘lowest common denominator’ of political philosophy, the intellectual forebear of much of today’s political orthodoxy, a role that befits a thinker of a naturally orthodox turn of mind. 88 He also â€Å"fitted the times very well (Bertrand Russell even described him as the ‘apostle of the Revolution of 1688’). 89 His philosophy was actively adopted by contemporary politicians and thinkers; his influence was transmitted to eighteenth-century France through the medium of Voltaire’s writings, and inspired the principles of the French Revolution. 90 And his views would spread still more widely, through the writings of Thomas Paine, eventually shaping the American Revolution too. 91 Although Locke’s reputation as a philosopher rests almost entirely on the epistemological doctrines expressed in An Essay Concerning Human Understanding, he made a great and lasting contribution to political thought. 92 This contribution consists mainly in his Two Treatises of Government, especially in the Second Treatise. 93 It is usual to regard the First Treatise as being mainly of antiquarian interest. 94 It is in the Second Treatise that Locke presents his own ideas. 95 The proper title of the treatise is ‘An Essay Concerning the True, Original, Extent, and End of Civil Government. ’96 The master of Locke’s own residential college at Oxford, Balliol College, described Mr. Locke as the ‘master of taciturnity’, because he could not discover, through questioning and so on, Locke’s opinions on religious and political matters. 97 Before we proceed to his notion of the state of nature, we will first explore some of his major ideas. First is his account of the law of nature. There is no modern thinker that I’m aware of who makes natural law as important to his doctrine as does Locke. 98 The law of nature, Locke tells us, â€Å"willeth the peace and preservation of all mankind. †99 Locke adds, the â€Å"law of nature . . . obliges everyone; and reason which is that law, teaches all mankind who will but consult it, that being all equal and independent, no one ought to harm another in his life, health, liberty, or possessions. †100 Locke also offers the three fundamental rights: life, health, and property. These three rights can never be overruled even by the government. They are also our natural rights, they are pre-political, it means that they are already our rights even before the establishment of the government. The interesting thing about these fundamental rights is that it is paradoxical. There are two reasons for this paradox. The first is that, â€Å"our rights are less fully mine. †101 Our rights were given by God. Locke tells us, â€Å"For men, being all the workmanship of one Omnipotent and Infinitely Wise Maker, they are his property whose workmanship they are, made to last during his, not one another’s pleasure. †102 The second reason is that, â€Å"because our rights are unalienable, they are more deeply mine. †103 These three Lockean fundamental rights influenced the famous 1776 U. S. Declaration of Independence, â€Å"We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable rights, that among these are life, liberty, and the pursuit of happiness. †104 It’s like the ghost of John Locke who wrote this declaration, not Thomas Jefferson. Every sentence of this declaration has something like a Lockean spirit or fingerprint. This Lockean principle also influenced our present Constitution. Art. III, Sec. I of the 1987 Constitution states that, â€Å"No person shall be deprived of life, liberty, or property without due process of law, nor shall any person be denied the equal protection of the laws. †105 Next, his theory of private property. Locke’s â€Å"account of property; certainly, in many ways, one of the most characteristic doctrines of Lockean political thought. †106 In the beginning the whole world was America, explains Locke, meaning that the world was an unexploited wilderness, before, through the efforts of people, there came farms and manufactures and buildings and cities. 107 With these come trade, and money. 108 But although property is the foundation of political society, Locke traces its origin back not to commerce, but to ‘the conjugal union. ’109 The first society was between man and wife, and later their children. 110 Locke’s view of human nature is that we are very much the property-acquiring animal. 111 Locke tells us, â€Å"Every man has a property in his own person, this nobody has any right to but himself. The labor of his body and the work of his hands, we may say are properly his. †112 This is one of the major premises of Robert Nozick and other libertarian thinkers, that we own ourselves. Locke continues, â€Å"Whatsoever then he removes out of that state of nature has provided and left it in, he has mixed his labor with, and joined to it something that in his own and thereby makes it his property. †113 Locke anticipates Marx’s Labor Theory of Value. Locke continues, â€Å"For this labor being the unquestionable property of the laborer no man but he can hence a right, to what that is once joined to, at least where there is enough and as good left in common for others. †114 Locke adds, â€Å"As much land as a man tills, plants, improves, cultivates and can use the product of, so much is his property. He by his labor, does as it were, enclose it from the common. †115 One of the most famous passages in the Second Treatise is that, â€Å"God gave the world to men in common, but since He gave it to them for their benefit and the greatest conveniences of life that they were capable to draw from it . . . it cannot be supposed He meant it should always remain common and uncultivated. He gave it to the use of the industrious and the rational and not to the fancy or covetousness of the quarrelsome and contentious. †116 Locke seems to suggest, that the state will be a commercial state, that the Lockean republic, the Lockean state will be a commercial republic. 117 Labor becomes, for Locke, his source of all value and our title to common ownership and in a remarkable rhetorical series of shifts, he makes not nature, but rather human labor and acquisition the source of property and of unlimited material possessions. 118 The new politics of the Lockean state will no longer be concerned with glory, honor, thumos, virtue, but Lockean politics will be sober, will be pedestrian, it will be hedonistic, without sublimity or joy. 119 Locke is the author of the doctrine that commerce softens manners, that it makes us less warlike, that it makes us civilized. 120 On the ground of Locke’s claim of self-ownership as the foundation of rights and justice, I will offer one of the major criticisms to this view. This is the ‘difference principle’ of one of my favorite political philosophers, John Rawls. First, â€Å"Lockean theory of justice, broadly speaking, supports a meritocracy sometimes referred to as ‘equality of opportunity’, that is, what a person does with his or her natural assets belongs exclusively to him, the right to rise or fall belongs exclusively to him. †121 Rawls’ principle â€Å"maintains that our natural endowments, our talents, our abilities, our family backgrounds, our history, our unique histories, our place, so to speak, in the social hierarchy, all of these things are from a moral point of view something completely arbitrary. 122 None of these are ours in any strong sense of the term. 123 They do not belong to us but are the result of a more or less kind of random or arbitrary genetic lottery or social lottery of which I or you happen to be the unique beficiaries. 124 No longer can I be regarded as the sole proprietor of my assets or the unique recipient of the advantages or disadvantages I may accrue from them. 125 Rawls concludes, I should not be regarded as a possessor but merely the recipient of what talents, capacities, and abilities that I may, again, purely arbitrary happen to possess. 126 The difference principle is a principle for institutions, not for individuals. 127 This is not to say that the difference principle does not imply duties for individuals – it creates innumerable duties for them. 128 It means rather that the difference principle applies in the first instance to regulate economic conventions and legal institutions, such as the market mechanism, the system of property, contract, inheritance, securities, taxation, and so on. 129 The direct application of the difference principle to structure economic institutions and its indirect application to individual conduct, exhibit what Rawls means when he says that the ‘primary subject of justice is the basic structure of society. ’130 The basic structure of society consists of the arrangement of the political, social, and economic institutions that make social cooperation possible and productive. 131 These institutions have a profound influence on individuals’ everyday lives, their characters, desires, and ambitions, as well as their future prospects. 132 The difference principle also â€Å"requires that economic institutions be designed so that the least advantaged class enjoys a greater share of income, wealth, and economic powers more generally, than it would under any other economic arrangement (with the important qualification that the final distribution is compatible with equal basic liberties and fair equal opportunities). 133 We should follow the principle that would be chose under ideal conditions not because it is rational for us to use such a procedure (in the narrow sense of rationality), and not because doing so would maximize total overall utility, but because doing so embodies fundamental values to which Rawls thinks, we are already committed, the values of freedom and equality. 134 In structuring a just society, we must also employ what Rawls called ‘the veil of ignorance’. The situation where you don’t know who you will be. 135 Using the DP and the veil of ignorance, we can assure that the cake will be sliced equally. There are other important Lockean ideas, that I wish to address, but for the main reason of limiting my paper, I won’t discuss them anymore. These important ideas are the Lockean idea of a limited government (which resembles our present form of government), his ‘Appeal to Heaven’ doctrine or the right of the people to rebel against an unjust government (this doctrine is also embodied in the Art. II, Sec. I, of the 1987 Constitution), and his famous doctrine of consent. Now, let’s proceed to the Lockean version of the state of nature. Like Hobbes, Locke makes use of the idea of a state of nature as an explanatory conceit which to build his political theory. 136 As with Hobbes, and despite some ambiguity of language, the argument is not really a historical one. 137 Locke does not take Hobbes’ pessimistic view of how ungoverned human beings would behave in relation to each other. 138 Unlike Hobbes, he does not depict the state of nature as an intolerable condition in which the amenities of civilization are impossible. 139 The drawbacks of Locke’s state of nature would be no worse than ‘inconveniences’. 140 The ‘continous inconveniences’ is that men in the state of nature were both the judge and executor of the law of nature. Locke tells us, â€Å"The execution of the law of nature is, in that state, put into every man’s hands, whereby everyone has a right to punish the transgressor of that law to such a degree as may hinder its violation. †141 Everyone can enforce the law of nature. Locke adds, â€Å"One may destroy a man who makes war upon him . . . for the same reason that he may kill a wolf or a lion; because such man . . . have no other rule, but that of force and violence, and he may be treated as beasts of prey, those dangerous and noxious creatures, that will be sure to destroy the, whenever he feels into their power. †142 How can we escape the ‘inconveniences’ of Locke’s state of nature? Civil government is the proper remedy for the inconveniences of the state of nature. 143 Just like his great predecessor Hobbes, we must mutually agree to give up our enforcement power by means of a social contract. Locke tells us, â€Å"Men being, as has been said, by nature, all free and equal and independent, no one can be put out of this estate, and subjected to the political power of another, without his own consent . . . when any number of men have, by the consent of every individual, made a community, they have thereby made that community one body, with a power to act as one body, which is only by the will and determination of the majority . . . to move . . . whither the greater force carries it. †144 Locke has no particular view about the form of government should take, as long as it is based on popular consent. 145 It may be a republic, but it could be an oligarchy and there might still be a monarch. 146 But whatever form the government takes, Locke says, it does need to include some ‘separation of powers’, and sets out fairly precisely the distinction to be made between the law-making part of government – the legislature – and the action-taking part – the executive. 147 The executive must have the power to appoint and dismiss the legislature, but it does not make the one superior to the other, rather there exists a ‘fiduciary trust’. 148 According to Locke’s view of government, there are only two parties to the trust: the people, who is both trustor and beneficiary, and the legislature, who is trustee. 149 The principal characteristic of a trust is the fact that the trustee assumes primarily obligations rather than rights. 150 The purpose of the trust is determined by the interest of the beneficiary and not by the will of the trustee. 151 The trustee is little more than a servant of both trustor and beneficiary, and he may be recalled by the trustor in the event of neglect of duty. 152 Locke also tells us that, â€Å"The great and chief end, therefore, of men’s uniting into commonwealths and putting themselves under government is the preservation of their property. †153 Property here is the general term for life, liberty, and estates or possessions. This Lockean idea is also embodied in the famous The Federalist No. 10 of James Madison, â€Å"The diversity in the faculties of men from which the rights of property originate, is not less an insuperable obstacle to a uniformity of interests. The protection of these faculties is the first object of government. †154 Locke – jointly, perhaps, with Hobbes – is the most influential of all English political theorist. 155 His political writing, like all political writing, is a response to the issues and events of a specific time and place, and reflects a particular perception of those issues and events. 156 Locke creates a picture of the world in which ‘rationality’ is the ultimate authority, not God, and certainly not, as Hobbes had insisted brute force. 157 He insists that people have certain fundamental rights and also attempt to return the other half of the human race, the female part, to their proper, equal, place in history, the family and government. 158 Locke’s legacy is the first, essentially practical, even legalistic, framework and analysis of the workings of society. 159 That is his own particular contribution to its evolution. 160 â€Å"Man is born free; and everywhere he is in chains. † -the citizen of Geneva (Jean-Jacques Rousseau), The Social Contract161. Rousseau was born in Geneva in 1712, the son of a Calvinist watchmaker. 162 It was his father who brought him up, his mother having died in childbirth. 163 His father also gave Rousseau a great love of books, but otherwise he had little formal education. 164 At the age of fifteen he ran away from home and began a life of solitary wandering. 165 His was a difficult, hypersensitive personality, with a towering sense of his own genius. 166 Although capable of intense friendship, his relationships never lasted. 167 After leaving Switzerland, Rousseau lived in Savoy and worked in Italy, before gravitating to Paris, at the time the leading intellectual centre in Europe. 168 There he associated with the Enlightenment thinkers – the philosophes – and particularly Diderot. 169 Rousseau contributed articles (mainly on musicology) to their great project, the Encyclopedia, but although he subscribed to some of their beliefs he was never a committed member of the group. 170 He developed his own ideas that differed radically from their fashionable cult of reason and from establishment orthodoxy. 171 Indeed, Rousseau’s most striking characteristic is his originality. 172 He changed the thinking of Europe, having an impact on political theory, education, literature, ethics, ideas about the self and its relationship to nature, and much else. 173 These influences, together with his elevation of emotion and will above reason, make him the major precursor of the Romantic movement. 174 His early ‘Discourses’ offended the philosophes, while his two most famous works, Emile and The Social Contract (both 1762), outraged the authorities, particularly because of their.

Intravenous Fluid Therapy During Anaesthesia

Intravenous Fluid Therapy During Anaesthesia INTRAVENOUS FLUID THERAPY DURING ANESTHESIA Water, Electrolytes, Glucose requirement, Disposition The intravascular compartment consists of blood cells, colloids, and solutes. Each one of them plays a specific role in the homeostasis. In the perioperative period there are losses and shifts of ECF between compartments. Injury, surgery, endocrine pathology contribute to those shifts and ultimately influence outcome. It is generally accepted that the total body water of a 70kg adult patient is approximately 60-70% of the weight and approximately two-thirds of it is intracellular. The focus of this chapter is the intravascular volume which consists of extracellular volume, plasma, and intracellular volume attributable to erythrocytes, leukocytes, platelets. The plasma, constituting approximately 3 L, consists of inorganic ions, albumin and small molecules. The inorganic ions are found on both sides of the cellular membranes and their concentration is maintained due to an energy consuming process. The Na+/K+ ATP-dependent pump maintains a higher N+ and Cl concentration in the extracellular space while K+ concentration is higher intracellularly. The albumin and other larger molecules are kept in the intravascular compartment by the endothelium cells due to their size. Smaller molecules, however, can cross freely this barrier. The endothelium cells and thus the barrier they provide can be disrupted by injury, surgery, or inflammatory processes. The result Is a disruption of homeostasis with significant deleterious effects on the body. Additionally, disease states can cause disruption of the inorganic ion homeostasis and leading to fluids shifts between compartments leading to edema, poor perfusion, lactate buildup, poor excretion of harmfu l metabolites and causing additional injury. Starlings Equation underscores the important forces (hydrostatic and oncotic) affecting fluid distribution between capillary and interstitial space: Jv = Kf [(Pc Pi) à Ã‚ ­ (Ï€c Ï€i)] Jv net filtration or net fluid movement Kf filtration coefficient Pc and Pi the hydrostatic pressures in the capillaries and interstitial space respectively à Ã‚ ¬ reflection coefficient Ï€c and Ï€i capillary and interstitial oncotic pressure The natural driving force and thus fluid movement is from capillary to interstitial space, where the excess fluid is cleared by the lymphatics. Diseases and trauma, whether due to surgery or otherwise induced and leading to inflammation and release of toxic substrates, disrupts the balance and the function of the endothelium and reducing the reflection coefficient. The increased permeability can lead to changes in the interstitial fluid composition which changes the oncotic pressure difference leading to further extravasation of fluid and resulting in tissue edema. This edema compromises local perfusion and accumulation of toxic byproducts causing a vicious cycle and ultimately death. The osmotic pressure is due to semipermeable membranes. Solutes which freely traverse a membrane dont build an osmotic pressure gradient across the membrane. Glucose is present in the intracellular fluid and serves to provide energy substrate. It is regulated through insulin and maintained at a level between 70 and 90 mmol/L in healthy adults. Increase in the glucose concentration can change the osmotic pressure across the endothelium and cause fluid shifts leading to Our goal as anesthesiologist is to maintain the intravascular compartment and assure adequate delivery of oxygen and nutrients to the organs while maintain good clearance of metabolic byproducts. The following classification of the perioperatively used fluids is ubiquitous: crystalloids and colloids. Crystalloids with ionic solution and osmolality close to that of plasma are deemed balanced solutions. The glucose is used to provide energy substrate and used in hypoglycemic patients or in combination with insulin. Once the glucose is metabolized, the reminder of the free water can be easily distributed along all compartments. Colloids consist of dissolved large molecular substances. They are generally described by their molecular weight or MWw. This property contributes to the oncotic pressure created intravascularly with intact endothelium and glycocalyx. Naturally occurring colloids encompass albumin, immunoglobulins, fresh frozen plasma, and plasma protein fraction. Semisynthetic ones are: gelatins, dextrans, and hydroxyethyl starches (HES). Semisynthetic and naturally occurring colloids have raised the concern of viral and prion transmission, particularly those from bovine origin. While most of the colloids have variable size of molecules, human albumin is more uniform. Gelatins are bovine collagen derivatives. Some preparations can contain Ca or other inorganic ions and those need to be taken into consideration. Dextrans are biosynthesized sucrose derivatives. They are best described by their molecular weight, i.e. Dextran 40 has a molecular size of 40,000 Daltons (Da) and Dextran 70 70,000 Da. Their clearance is highly dependent on their molecular size with smaller molecules freely filtered through the renal glomerulum and larger sizes are metabolized by the reticular endothelial system first and then excreted through the gut. Hetastarches are derivatives of amylopectine. They are divided into high-molecular weight, medium molecular weight and low molecular weight. They can be dissolved into normal saline or balanced solution. All semisynthetic colloids are known to exert an effect on kidneys and coagulation. Thus, there is a maximum dose recommended by the manufacturers. FluidRequirementsandFluidDeficitCalculations Normal Salinevs.LactatedRingersvs. Plasmalytevs.D5W